Midtown Manhattan, or simply Midtown, represents the middle portion of the borough and island of Manhattan in New York City, as noted along the long axis of the island. Midtown is home to some of the city's most iconic buildings, including the Empire State Building, the Chrysler Building, and the United Nations Headquarters, and it contains world-famous commercial zones such as Rockefeller Center, Broadway, and Times Square. Midtown Manhattan separates Lower Manhattan from Upper Manhattan. 

Midtown Manhattan is the largest central business district in the United States and ranks among the most intensely used pieces of real estate in the world. While Lower Manhattan is the main financial center, Midtown is the country's largest commercial, entertainment, and media center; Midtown Manhattan is also a growing financial center, second in importance in the United States only to Lower Manhattan's Financial District. The majority of New York City's skyscrapers, including its tallest hotels and apartment towers, lie within Midtown. The area hosts commuters and residents working in its offices, hotels, and retail establishments; many tourists, visiting residents, and students populate the district. Some areas, such as Times Square and the Fifth Avenue corridor, have large clusters of retail stores, and Times Square is the center of Broadway theatre. The Avenue of the Americas holds the headquarters of three of the four major U.S. television networks.